WakeSHARE (Aging & Alzheimer's Resources)

Wake Forest Pepper Study Registry (PSR)

How to search: Enter any single word, or combination of words using " + " (space plus space) in between. As an example, to search for both male and female with a condttion of obesity that have DEXA, enter "DEXA + Obesity + M/F". Clicking a column header will sort the data by that column's data.
Notes: Most studies will have some available demographic and many will have laboratory data. An asterisks (*) indicate study collected by not available in the database.

Study (PI)	Gender	Age	Disease/ Condition	N=	Design / Intervention	Biospecimen	Imaging	Physical	Activity Monitoring	Cognitive / Depression
ADAPT (Messier, WFU)	M/F	60 +	knee osteoarthritis	316	exercise / diet 18 mos			Gait Speed PAT-D		MMSE CES-D
AML (Klepin, WFU)	M/F	60 +	AML	81	Parallel Assignment 24 weeks			Grip Strength SPPB PAT-D Knee Extensor		3MSE CES-D
APPLE (Nicklas, WFU)	M/F	65 -79	Arthritis, OA, weight loss	40	weight loss: no vest vs weighted vest 22 weeks	Serum Plasma Adipose	DEXA	Gait Speed ESPPB Leg Press Knee Extensor		MoCA CES-D
Bicarb (Petrovic, WFU)	M/F	65 +	Kidney disease / disability	80	3 months RCT oral bicarbonate supplement vs placebo	Serum Plasma Urine	DEXA	Gait Speed SPPB		MoCA
BRJS (Miller, WFU)	M/F	60 -84		27	randomized, double blind, placebo-controlled trial	Plasma	CT DEXA	Gait Speed Knee Extensor
CLIP (Rejeski, WFU)	M/F	60 -79	Overweight/obese; CVD or METs	288	18-month RCT Caloric Restriction and/or Aerobic Exercise	Serum Plasma	DEXA	Gait Speed SPPB PAT-D
CLIP II (Rejeski, WFU)	M/F	60 -79	cardiovascular disease	252	Weight Loss alone, aerobic exercise training +Weight Loss or resistance exercise training +Weight Loss 18 mos		DEXA*	SPPB* Knee Extensor*	Actigraph (Hip)*
DEMO (Nicklas, WFU)	F	50 -70	Abdominal obesity	112	5-month RCT Caloric Restriction vs. CR + Aerobic Exercise	Serum Plasma Adipose DNA	DEXA	Grip Strength SPPB PAT-D		MMSE CES-D
EFFECT - Pilot (Morris, WFU)	M/F	18 +	ICU patients	100	Cross-sectional Intensive physical therapy vs. Usual Care	Serum Plasma DNA
EMPOWER (Nicklas, WFU)	M/F	65 -85	Obesity	189	Randomized to 3 treatment arms 18 mos	Serum Plasma	DEXA	Gait Speed Grip Strength ESPPB	ActivPAL*	DSST MoCA CES-D
EVIDENCE (Houston, WFU)	M/F	65 +	Vitamin D Insufficient	200	Vitamin D vs Placebo 12 month	Serum Muscle		Gait Speed Grip Strength SPPB ESPPB Leg Press Knee Extensor CHAMPS Postural Sway Gait Rite		DSST MoCA Story Recall* CES-D
EVIDENCE Sub Study (Molina, WFU)	M/F	65 +	Vitamin D Insufficient	40	Vitamin D & Muscle Function 4 months	Serum Plasma		Gait Speed Grip Strength SPPB ESPPB Leg Press		MoCA
FIT (F/U Infinite) (Nicklas, WFU)	M/F	65 -80	obesity, follow up to INFINITE Study	0	18 mos	Plasma DNA		Gait Speed ESPPB CHAMPS*		DSST MMSE CES-D
FLOW (Hundley, WFU)	M/F	50 +	Aging/Heart Failure	30	Cross-sectional N/A	Serum Plasma		Grip Strength SPPB PAT-D
GO MET (Ding, WFU)	M/F	65 -79	CAD / Cancer / MCI / Physcial Function Decline	30	Crossover Metformin vs Placebo 24 months	Serum Plasma DNA		Gait Speed Grip Strength ESPPB PAT-D Leg Press Knee Extensor*		DSST MoCA
Healthy Aging (Kitzman, WFU)	M/F	60 +	Healthy controls	61	Cross-sectional N/A	Serum Plasma Urine Muscle DNA	DEXA	Gait Speed Grip Strength SPPB PAT-D Leg Press Knee Extensor CHAMPS	ActivPAL*	MMSE Rey AVLT* Trail Making*
HOPE - Pilot (Houston, WFU)	M/F	55 +	Obesity	54	Exercise Study Follow up / Feasibility Study n/a		DEXA	Gait Speed Grip Strength ESPPB Leg Press Knee Extensor*		DSST* MoCA Rey AVLT* TICS* Trail Making* CES-D*
I'M FIT (Nicklas, WFU)	M/F	65 -79	Obese; at risk for disability	130	5-month RCT Resistance Training (RT) vs. Resistance Training (RT) + Caloric Restriction	Serum Plasma Muscle Adipose	CT DEXA	Gait Speed Grip Strength SPPB ESPPB PAT-D Leg Press Knee Extensor		MMSE
IDEA (Messier, WFU)	M/F	55 +	Overweight/obese; Knee OA	450	18-month RCT Caloric Restriction vs. Aerobic Exercise vs. CR+AEX	Serum Plasma Urine DNA	CT DEXA	Gait Speed Grip Strength SPPB PAT-D Leg Press	ActivPAL*	DSST MMSE 3MSE CES-D
INFINITE (Nicklas, WFU)	M/F	65 -79	Obese	180	5-month RCT Aerobic Exercise vs AEX + Hi Caloric Restriction vs AEX + Low Caloric Restriction	Serum Plasma Adipose DNA	DEXA	Gait Speed SPPB PAT-D	RT3*	DSST MMSE Rey AVLT* COWA* Stroop* CES-D
LEAN (Nickals, WFU)	M/F		Obesity	0		Serum Plasma Muscle	CT DEXA	Gait Speed Grip Strength ESPPB PAT-D Leg Press Knee Extensor		MMSE
LIFE - Pilot (Kritchevsky, WFU)	M/F	70 -89	At risk for disability	424	12-month RCT Aerobic + Resistive Exercise vs. Control	Serum Plasma DNA	DEXA*	Gait Speed Knee Extensor*		CES-D*
LOSE-IT (Miller, WFU)	M/F	18 +	Bariatric surgery patients	42	Cross-sectional N/A	Serum Plasma Muscle Adipose	CT DEXA	SPPB PAT-D Knee Extensor*		CES-D
MAT-PAC (Kim, WFU)	M/F	65 +	Mobility	0	observational
Medifast (Beavers, WFU)	M/F	65 -79	Obesity	124	Weight Loss (High Protein Group) / Weight Stable group 24 mos	Serum Plasma Urine	DEXA*	Gait Speed Grip Strength ESPPB PAT-D Leg Press	Actigraph (Wrist)*	DSST MoCA CES-D
MORPH (Brooks, WFU)	M/F	55 -85	Obesity / Pain	35	(2) a two group randomized controlled pilot trial (RCT) in 35 obese (BMI=30-45 kg/m2), low-active, older (55-85 years) adults with chronic pain randomized to either 12-weeks of active intervention or a wait-list control. 12 weeks			ESPPB		MoCA CES-D
MOW Vitamin D (Houston, WFU)	M/F	65 +	Vitamin D Insufficient	68	100,000 IU OF VITAMIN D VS PLACEBO (400 IU VIT E) AND FALLS ASSESSMENT 5 month Randomized Control Trial	Serum Plasma		PAT-D
OPTIFAST (Ard, WFU)	M/F	64 +	Obesity / Disability	88	high intensity weight loss protocol VS a moderate intensity weight loss protocol 26 weeks		DEXA	Gait Speed ESPPB Knee Extensor		DSST MoCA
OPTIMA (Kritchevsky, WFU)	M/F	65 -79	Overweight/obese; at risk for disability	88	6-month RCT Caloric Restriction + Pioglitazone vs. CR + Resistance Exercise	Serum Plasma Muscle	CT DEXA	Gait Speed Grip Strength SPPB ESPPB PAT-D Leg Press Knee Extensor* CHAMPS		MMSE CES-D
PA AML (Klepin, WFU)	M/F	60 +	Acute Myeloid Leukemia	70	Interventional Clinical Trial Parallel Assignment			Grip Strength SPPB PAT-D		DSST CES-D
PACT (Miller, WFU)	M/F	60 +	Overweight/obese; Knee OA	84	6-month RCT Caloric Restriction + Exercise vs. Control	Serum Plasma Muscle DNA	DEXA	Gait Speed PAT-D*
PAIN (Brooks, WFU)	M/F	65 +	chronic pain	33	observational 3 months			SPPB PAT-D
PART - Transplant (Hartmann, WFU)	M/F	60 +	Renal Transplant	30	physical activity 3 months	Serum Urine	DEXA	Gait Speed Grip Strength SPPB PAT-D Leg Press CHAMPS	Actigraph (Hip)*	MMSE CES-D
PIE (Kitzman, WFU)	M/F	60 +	Diastolic heart failure	80	12-month RCT ACE inhibitor use vs Placebo	Serum Plasma Muscle DNA	DEXA	Grip Strength SPPB PAT-D
PIE II (Kitzman, WFU)	M/F	60 +	Diastolic heart failure	80	12-month RCT Spironolactone vs Placebo	Serum Plasma Muscle DNA	DEXA	Grip Strength SPPB PAT-D
POWER (Marsh, WFU)	M/F	65 +	At risk for disability	45	3-month RCT Strength training vs. Power training vs. Control	Serum Plasma Muscle	DEXA	SPPB PAT-D		CES-D
PREDICT (Hundley, WFU)	M/F	55 -85	At risk for CHF	608	Longitudinal cohort N/A	Serum DNA	MRI	Gait Speed Grip Strength SPPB PAT-D Leg Press
RAINS (Kritchevsky, WFU)	M/F	65 -85	Overweight/obese; at risk for disability	67	4-month intervention Nutrition (protein) supplementation	Serum Plasma
REACT II (Berry, WFU)	M/F	37 -95	COPD	200	12-month RCT Aerobic Exercise	Serum Plasma DNA	DEXA	Grip Strength SPPB PAT-D Knee Extensor*		CES-D
REACT III (Berry, WFU)	M/F	45 -80	COPD	32	4-month RCT Resistance Exercise vs. Control	Serum Plasma Muscle DNA
SECRET (Kitzman, WFU)	M/F	60 +	Overweight/obese; heart failure	100	5-month RCT Caloric Restriction vs. Aerobic Exercise vs. CR+AEX	Serum Plasma Muscle DNA	DEXA	Gait Speed Grip Strength SPPB PAT-D Leg Press	ActivPAL*
SECRET-II (Kitzman, WFU)	M/F	60 +	HFpEF	88	CR+AT vs CR+AT+FT 24 weeks		MRI DEXA*	Gait Speed SPPB*		CES-D*
SILVER (Beavers, WFU)	M/F	60 -79	Obesity	24	hypocaloric dietary intervention soy based meal replacemts vs animal protein based MR 3 months	Serum Muscle DNA	CT DEXA	Gait Speed Grip Strength SPPB ESPPB* Knee Extensor		MMSE
Skeletal MRI (Kitzman, WFU)	M/F	60 +	Exercise Intolerance, Heart failure, preserved ejection fraction	20	This study will enroll 20 participants. 10 participants will be 60 years and older, have been diagnosed with HFpEF, and suffer exercise intolerance. The remaining 10 participants will be in the age and sex matched control group. 4 weeks	Serum Plasma	MRI	Gait Speed Grip Strength SPPB Knee Extensor		CES-D*
START (Messier, WFU)	M/F	50 +	Arthritis	372	randomized trial 18 mos					MoCA*
SWALLOW (Butler, WFU)	M/F	18 -100	swallowing disorder	220			CT	Gait Speed Grip Strength SPPB PAT-D		DSST MMSE CES-D
TRAIN (Kritchevsky, WFU)	M/F	55 +	Heart Failure	294		Serum Plasma Urine	DEXA	Grip Strength SPPB PAT-D		CES-D
UNITS (Parker-Autry, WFU)	F	70 +	Urinary Incontinence	71	Interventional (Clinical Trial) Parallel Assignment	Urine	DEXA*	Gait Speed Grip Strength ESPPB PAT-D Knee Extensor Postural Sway		MoCA CES-D
UPLIFT (Houston, WFU)	M/F	65 -85	Obesity	187	Interventional (Clinical Trial) 18 mos		CT DEXA	Gait Speed Grip Strength SPPB* ESPPB Knee Extensor CHAMPS		DSST MoCA CES-D
Vitamin D Supplement (Houston, WFU)	M/F	70 -89	Vitamin D insufficient	26	4-month RCT Vitamin D + Calcium supplementation vs. calcium only	Serum Plasma Muscle	DEXA	Gait Speed Grip Strength SPPB PAT-D Leg Press Knee Extensor* Postural Sway*		DSST* MoCA* MMSE Story Recall* CES-D*
Study (PI)	Gender	Age	Disease/ Condition	N=	Design / Intervention	Biospecimen	Imaging	Physical	Activity Monitoring	Cognitive / Depression

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Wake Forest Pepper Study Registry (PSR)