Pepper Study Registry (PSR)

Learn About Wake Forest's Aging Resources

How to search: Enter any single word, or combination of words using " + " (space plus space) in between. As an example, to search for both male and female with a condttion of obesity that have DEXA, enter "DEXA + Obesity + M/F". Clicking a column header will sort the data by that column's data.
Notes: Most studies will have some available demographic and many will have laboratory data. An asterisks (*) indicate study collected by not available in the database.
Study (PI) Gender Age Disease/
Condition
N= Design /
Intervention
Biospecimen Imaging Physical Activity
Monitoring
Cognitive /
Depression
ADAPT
(Messier, WFU)
M/F 60 + knee osteoarthritis 316 exercise / diet
18 mos

Gait Speed
PAT-D
MMSE
CES-D
APPLE
(Nicklas, WFU)
M/F 65 -79 Arthritis, OA, weight loss 40 weight loss: no vest vs weighted vest
22 weeks
Serum
Plasma
Adipose
DEXA
Gait Speed
ESPPB
Leg Press
Knee Extensor
MoCA
CES-D
Bicarb
(Petrovic, WFU)
M/F 65 + Kidney disease / disability 80 3 months RCT
oral bicarbonate supplement vs placebo
Serum
Plasma
Urine
DEXA
Gait Speed
SPPB
MoCA
CLIP
(Rejeski, WFU)
M/F 60 -79 Overweight/obese; CVD or METs 288 18-month RCT
Caloric Restriction and/or Aerobic Exercise
Serum
Plasma
DEXA
Gait Speed
SPPB
PAT-D
CLIP II
(Rejeski, WFU)
M/F 60 -79 cardiovascular disease 252 Weight Loss alone, aerobic exercise training +Weight Loss or resistance exercise training +Weight Loss
18 mos
DEXA*
SPPB*
Knee Extensor*
Actigraph (Hip)*
DEMO
(Nicklas, WFU)
F 50 -70 Abdominal obesity 112 5-month RCT
Caloric Restriction vs. CR + Aerobic Exercise
Serum
Plasma
Adipose
DNA
DEXA
Grip Strength
SPPB
PAT-D
MMSE
CES-D
EFFECT - Pilot
(Morris, WFU)
M/F 18 + ICU patients 100 Cross-sectional
Intensive physical therapy vs. Usual Care
Serum
Plasma
DNA

EMPOWER
(Nicklas, WFU)
M/F 65 -85 Obesity 189 Randomized to 3 treatment arms
18 mos
Serum
Plasma
DEXA
Gait Speed
Grip Strength
ESPPB
ActivPAL*
DSST
MoCA
CES-D
EVIDENCE
(Houston, WFU)
M/F 65 + Vitamin D Insufficient 200 Vitamin D vs Placebo
12 month
Serum
Muscle

Gait Speed
Grip Strength
SPPB
ESPPB
Leg Press
Knee Extensor
CHAMPS
Postural Sway
Gait Rite
DSST
MoCA
Story Recall*
CES-D
EVIDENCE Sub Study
(Molina, WFU)
M/F 65 + Vitamin D Insufficient 40 Vitamin D & Muscle Function
4 months
Serum
Plasma

Gait Speed
Grip Strength
SPPB
ESPPB
Leg Press
MoCA
FIT (F/U Infinite)
(Nicklas, WFU)
M/F 65 -80 obesity, follow up to INFINITE Study 0
18 mos
Plasma
DNA

Gait Speed
ESPPB
CHAMPS*
DSST
MMSE
CES-D
FLOW
(Hundley, WFU)
M/F 50 + Aging/Heart Failure 30 Cross-sectional
N/A
Serum
Plasma

Grip Strength
SPPB
PAT-D
GO MET
(Ding, WFU)
M/F 65 -79 CAD / Cancer / MCI / Physcial Function Decline 30 Crossover Metformin vs Placebo
24 months
Serum
Plasma
DNA

Gait Speed
Grip Strength
ESPPB
PAT-D
Leg Press
Knee Extensor*
DSST
MoCA
Healthy Aging
(Kitzman, WFU)
M/F 60 + Healthy controls 61 Cross-sectional
N/A
Serum
Plasma
Urine
Muscle
DNA
DEXA
Gait Speed
Grip Strength
SPPB
PAT-D
Leg Press
Knee Extensor
CHAMPS
ActivPAL*
MMSE
Rey AVLT*
Trail Making*
HOPE - Pilot
(Houston, WFU)
M/F 55 + Obesity 54 Exercise Study Follow up / Feasibility Study
n/a
DEXA
Gait Speed
Grip Strength
SPPB*
ESPPB
Leg Press
Knee Extensor*
DSST*
MoCA
Rey AVLT*
TICS*
Trail Making*
CES-D*
I'M FIT
(Nicklas, WFU)
M/F 65 -79 Obese; at risk for disability 130 5-month RCT
Resistance Training (RT) vs. Resistance Training (RT) + Caloric Restriction
Serum
Plasma
Muscle
Adipose
CT
DEXA
Gait Speed
Grip Strength
SPPB
ESPPB
PAT-D
Leg Press
Knee Extensor
MMSE
IDEA
(Messier, WFU)
M/F 55 + Overweight/obese; Knee OA 450 18-month RCT
Caloric Restriction vs. Aerobic Exercise vs. CR+AEX
Serum
Plasma
Urine
DNA
CT
DEXA
Gait Speed
Grip Strength
SPPB
PAT-D
Leg Press
ActivPAL*
DSST
MMSE
3MSE
CES-D
INFINITE
(Nicklas, WFU)
M/F 65 -79 Obese 180 5-month RCT
Aerobic Exercise vs AEX + Hi Caloric Restriction vs AEX + Low Caloric Restriction
Serum
Plasma
Adipose
DNA
DEXA
Gait Speed
SPPB
PAT-D
RT3*
DSST
MMSE
Rey AVLT*
COWA*
Stroop*
CES-D
LIFE - Pilot
(Kritchevsky, WFU)
M/F 70 -89 At risk for disability 424 12-month RCT
Aerobic + Resistive Exercise vs. Control
Serum
Plasma
DNA
DEXA*
Gait Speed
Knee Extensor*
CES-D*
LOSE-IT
(Miller, WFU)
M/F 18 + Bariatric surgery patients 42 Cross-sectional
N/A
Serum
Plasma
Muscle
Adipose
CT
DEXA
SPPB
PAT-D
Knee Extensor*
CES-D
MAT-PAC
(Kim, WFU)
M/F 65 + Mobility 0 observational

Medifast
(Beavers, WFU)
M/F 65 -79 Obesity 124 Weight Loss (High Protein Group) / Weight Stable group
24 mos
Serum
Plasma
Urine
DEXA*
Gait Speed
Grip Strength
SPPB*
ESPPB
PAT-D
Leg Press
Actigraph (Wrist)*
DSST
MoCA
CES-D
MORPH
(Brooks, WFU)
M/F 55 -85 Obesity / Pain 35 (2) a two group randomized controlled pilot trial (RCT) in 35 obese (BMI=30-45 kg/m2), low-active, older (55-85 years) adults with chronic pain randomized to either 12-weeks of active intervention or a wait-list control.
12 weeks

ESPPB
MoCA
CES-D
MOW Vitamin D
(Houston, WFU)
M/F 65 + Vitamin D Insufficient 68 100,000 IU OF VITAMIN D VS PLACEBO (400 IU VIT E) AND FALLS ASSESSMENT
5 month Randomized Control Trial
Serum
Plasma

PAT-D*
OPTIFAST
(Ard, WFU)
M/F 64 + Obesity / Disability 88 high intensity weight loss protocol VS a moderate intensity weight loss protocol
26 weeks
DEXA
Gait Speed
ESPPB
Knee Extensor
DSST
MoCA
OPTIMA
(Kritchevsky, WFU)
M/F 65 -79 Overweight/obese; at risk for disability 88 6-month RCT
Caloric Restriction + Pioglitazone vs. CR + Resistance Exercise
Serum
Plasma
Muscle
CT
DEXA
Gait Speed
Grip Strength
SPPB
ESPPB
PAT-D
Leg Press
Knee Extensor*
CHAMPS
MMSE
CES-D
PACT
(Miller, WFU)
M/F 60 + Overweight/obese; Knee OA 84 6-month RCT
Caloric Restriction + Exercise vs. Control
Serum
Plasma
Muscle
DNA
DEXA
Gait Speed
PAT-D*
PAIN
(Brooks, WFU)
M/F 65 + chronic pain 33 observational
3 months

SPPB
PAT-D
PART - Transplant
(Hartmann, WFU)
M/F 60 + Renal Transplant 30 physical activity
3 months
Serum
Urine
DEXA
Gait Speed
Grip Strength
SPPB
PAT-D
Leg Press
CHAMPS
Actigraph (Hip)*
MMSE
CES-D
PIE
(Kitzman, WFU)
M/F 60 + Diastolic heart failure 80 12-month RCT
ACE inhibitor use vs Placebo
Serum
Plasma
Muscle
DNA
DEXA
Grip Strength
SPPB
PAT-D
PIE II
(Kitzman, WFU)
M/F 60 + Diastolic heart failure 80 12-month RCT
Spironolactone vs Placebo
Serum
Plasma
Muscle
DNA
DEXA
Grip Strength
SPPB
PAT-D
POWER
(Marsh, WFU)
M/F 65 + At risk for disability 45 3-month RCT
Strength training vs. Power training vs. Control
Serum
Plasma
Muscle
DEXA
SPPB
PAT-D
CES-D
PREDICT
(Hundley, WFU)
M/F 55 -85 At risk for CHF 608 Longitudinal cohort
N/A
Serum
DNA
MRI

Gait Speed
Grip Strength
SPPB
PAT-D
Leg Press
RAINS
(Kritchevsky, WFU)
M/F 65 -85 Overweight/obese; at risk for disability 67 4-month intervention
Nutrition (protein) supplementation
Serum
Plasma

REACT II
(Berry, WFU)
M/F 37 -95 COPD 200 12-month RCT
Aerobic Exercise
Serum
Plasma
DNA
DEXA
Grip Strength
SPPB
PAT-D
Knee Extensor*
CES-D
REACT III
(Berry, WFU)
M/F 45 -80 COPD 32 4-month RCT
Resistance Exercise vs. Control
Serum
Plasma
Muscle
DNA

SECRET
(Kitzman, WFU)
M/F 60 + Overweight/obese; heart failure 100 5-month RCT
Caloric Restriction vs. Aerobic Exercise vs. CR+AEX
Serum
Plasma
Muscle
DNA
DEXA
Gait Speed
Grip Strength
SPPB
PAT-D
Leg Press
ActivPAL*
SECRET-II
(Kitzman, WFU)
M/F 60 + HFpEF 88 CR+AT vs CR+AT+FT
24 weeks
MRI
DEXA*
Gait Speed
SPPB*
CES-D*
SILVER
(Beavers, WFU)
M/F 60 -79 Obesity 24 hypocaloric dietary intervention soy based meal replacemts vs animal protein based MR
3 months
Serum
Muscle
DNA
CT
DEXA
Gait Speed
Grip Strength
SPPB
ESPPB*
Knee Extensor
MMSE
Skeletal MRI
(Kitzman, WFU)
M/F 60 + Exercise Intolerance, Heart failure, preserved ejection fraction 20 This study will enroll 20 participants. 10 participants will be 60 years and older, have been diagnosed with HFpEF, and suffer exercise intolerance. The remaining 10 participants will be in the age and sex matched control group.
4 weeks
Serum
Plasma
MRI

Gait Speed
Grip Strength*
SPPB*
Knee Extensor*
CES-D*
START
(Messier, WFU)
M/F 50 + Arthritis 372 randomized trial
18 mos

MoCA*
TRAIN
(Kritchevsky, WFU)
M/F 55 + Heart Failure 294
Serum
Plasma
Urine
DEXA
Grip Strength
SPPB
PAT-D
CES-D
UNITS
(Parker-Autry, WFU)
F 70 + Urinary Incontinence 71 Interventional (Clinical Trial)
Parallel Assignment
Urine
DEXA*
ESPPB*
Knee Extensor*
Postural Sway*
MoCA*
UPLIFT
(Houston, WFU)
M/F 65 -85 Obesity 187 Interventional (Clinical Trial)
18 mos
CT
DEXA*
Gait Speed
Grip Strength*
SPPB*
ESPPB*
Knee Extensor*
DSST*
MoCA*
CES-D*
Vitamin D Supplement
(Houston, WFU)
M/F 70 -89 Vitamin D insufficient 26 4-month RCT
Vitamin D + Calcium supplementation vs. calcium only
Serum
Plasma
Muscle

Gait Speed
Grip Strength
SPPB
ESPPB*
PAT-D
Leg Press
Knee Extensor*
Postural Sway*
DSST*
MoCA*
MMSE
Story Recall*
CES-D*
Study (PI) Gender Age Disease/
Condition
N= Design /
Intervention
Biospecimen Imaging Physical Activity
Monitoring
Cognitive /
Depression

 

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